Orbital Aspergillosis: Voriconazole – The New Standard Treatment?

نویسندگان

  • Derek H. Ohlstein
  • Claudia Hooten
  • Javier Perez
  • Charles L. Clark
  • Hazem Samy
چکیده

BACKGROUND/AIM To describe a case of invasive orbital aspergillosis and evaluate treatments and outcomes. METHODS A case report and review of orbital aspergillosis treatment with voriconazole in the English language literature. CONCLUSION Amphotericin B with debridement is the current standard of care for orbital aspergillosis; however, its prognosis is unfavorable. When compared to amphotericin B, voriconazole demonstrates a survival benefit, has less systemic toxicity, and is better tolerated by patients. While a prospective trial comparing amphotericin B to voriconazole in orbital aspergillosis is not feasible, there is evidence to support the use of voriconazole as primary therapy.

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2012